No Northern trains will operate along the Hartlepool line to Newcastle and Middlesbrough on Saturday, August 26, and Friday, September 1.
Limited services are expected to run on Sunday, August 27, with confirmation of what if any trains will be operating on Saturday, September 2, still to be announced.
The RMT is taking industrial action on August 26 and September 2 with Aslef staging a one-day strike on September 1.
A statement from Northern read: “On days of limited services, last trains will be around 17.00 and are expected to be extremely busy.”
Grand Central, which runs trains from Hartlepool to Sunderland and London King’s Cross, is still expected to run trains on three of the four above dates.
The exception, due to separate engineering work, is August 27.
Further details are available from National Rail on 03457 48 49 50.