The actor, who plays teenager Charlie Spring in the acclaimed series, posted on Twitter that he has been targeted with homophobic abuse and cruel comments about his appearance.
Sharing a screenshot of the search bar with his name, the suggestions that come up after include the words "ugly" and "gay".
"Ahhh lovely," he commented on the post, adding: "Everyone should be entitled to an opinion, but just know we see most of the stuff people post online :)".
Heartstopper follows Charlie's blossoming romance with classmate Nick Nelson (Kit Connor), and has been praised for its positive and joyous portrayal of LGBTQ+ relationships.
Joe recently spoke to Digital Spy about the fan response to the series, saying: "It's been great. It's been overwhelming in a good way. They're all so supportive. It cushions out the overwhelmingness of it, just how lovely everyone is."
He added of what he hopes people get out of Heartstopper: "Every person who watches it will pick out different things that relate to their life. For me, I think it's just about letting yourself be yourself without anyone else telling you differently.
"It's being truthful to what you want, and not fitting into any sort of box. Especially Nick's journey in the story – he learns that he doesn't have to be a certain model to fit in. That's the same with many of the characters' stories. It's just general love."
While season 2 of the show is yet to be confirmed, Joe has suggested that a follow-up "could see the next chapter of Nick and Charlie's relationship" as per the original graphic novels the series is based on.
Heartstopper is streaming on Netflix.
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