The presenter, who is busy promoting Amazon series The Grand Tour, was on The Jonathan Ross Show when he was asked whether he would appear on the long-running ITV reality show.
Clarkson said: “We all say no now because we’ve all got jobs. If you’re down the line and somebody said, ‘Here’s a hundred thousand pounds to go and eat some maggots,’ count me in."
He added: "Yes, I’d go and do it – never say never to that."
“It's just a TV show – it's not The Bible,” he said, adding: "Do you think everyone on television should influence the views of others? Because I don't. It's not my job to be woke."
The latest series of I'm a Celebrity is drawing to a close this Sunday (8 December), with American TV personality Caitlyn Jenner, DJ Roman Kemp and Girls Aloud star Nadine Coyle expected to battle it out to become this year's winner.
The Jonathan Ross Show airs on 7 December at 10.25pm on ITV.