The Azzurri suffered defeats to Wales and Ireland in the opening rounds, while their controversial ruck tactics helped them limit England to a 21-point victory at Twickenham last time out.
France have won 17 of their last 19 meetings with Italy - winning each of the last four - but only scraped past the Italians 23-21 in last year's Championship.
Here’s the full breakdown ahead of Saturday's clash at the Stadio Olimpico…
The match kicks off at Stadio Olimpico at 1.30pm on Saturday, March 11.
TV AND LIVE COVERAGE
ITV will be broadcasting the match live with build-up from 12.30pm, while BBC Five Live Sports Extra will provide coverage on the radio.
You can follow the match live online by clicking here.
Italy have named three changes to the starting line-up for their home match against France
Injuries dictated the alterations for the gamein Rome, with Angelo Esposito restored to wing in place of Giulio Bisegni; Carlo Canna coming in at fly-half to replace Tommaso Allan and Leonardo Ghiraldini taking over as hooker from Ornel Gega.
Meanwhile, France have called up Francois Trinh-Duc to their squad for the weekend's Six Nations game against Italy, almost four months after he suffered a fractured arm.
Trinh-Duc, who can play fly-half or inside centre, broke his arm last November in a game against Samoa and returned to action with his club Toulon against Brive on Saturday in the Top 14.
Full-back Brice Dulin was also called up to the squad for the match in Rome on Saturday.
Italy XV: To be confirmed
France XV: To be confirmed
HEAD TO HEAD
BETTING ODDS (provided by 888Sport)
Italy to win at 17/2
Draw at 38/1
France to win at 1/17
Odds correct as of 5pm March 7. Click here to place a bet.