The Tinseltown A-listers tied the knot in 2000 but split in 2005, with Pitt going on to start a relationship with his Mr And Mrs Smith co-star Angelina Jolie.
“It was absolutely fun. Brad and I are buddies, we're friends," the 52-year-old told US radio star Howard Stern.
"And we speak, and there's no oddness at all, except for everyone that probably watched it and was wanting there to be, or assumed there to be.”
Aniston and Pitt were one of Hollywood’s golden couples for the five years they were married.
Fans were thrilled last year when they were reunited at the 2020 SAG Awards.
The pair were both up for gongs at the ceremony (with Pitt getting the nod for Once Upon A Time In Hollywood and Aniston recognised for The Morning Show) and they bumped into each other backstage.
Pictures showed them sharing a friendly chat and a hug.
Both stars have been married again since they divorced.
Pitt, 57, tied the knot with Jolie in 2014 but the actors have now gone their separate ways.
And Aniston was married to actor Justin Theroux from 2015 to 2017.
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