John Worboys has been charged with four sexual offences allegedly committed between 2000 and 2008, Scotland Yard has said.
The 61-year-old, who is now known as John Radford, faces two counts of administering a stupefying or overpowering drug with intent to commit rape or indecent assault.
He has also been charged with two counts of administering a substance with intent to commit a sexual offence.
A Crown Prosecution Service spokesperson said: "In September 2018, the Crown Prosecution Service received a file of evidence from the Metropolitan Police relating to allegations of non-recent sexual assault and of administering drugs to cause unconsciousness.
"Following a review of the evidence, the CPS has today charged John Radford, formerly known as John Worboys, with four offences."
He will appear at Westminster Magistrates' Court on 23 May.