Kidneys from genetically modified pig transplanted into brain-dead human

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Kidneys from genetically modified pig transplanted into brain dead human (Jeff Myers/UAB)
Kidneys from genetically modified pig transplanted into brain dead human (Jeff Myers/UAB)

In a world first, two kidneys from a genetically modified pig have been transplanted into the body of a brain-dead human – an achievement hailed as a “game-changing moment in the history of medicine”.

The process shows the procedure may be viable in the long term and how such a transplant might work in the real world, researchers say.

Experts now hope to carry out a clinical trial on living humans with serious kidney problems.

The transplanted organs were able to carry out the functions of kidneys, scientists from the University of Alabama at Birmingham (UAB) in the US report.

They successfully filtered blood, produced urine, and were not immediately rejected.

According to the study, the kidneys continued working until 74 hours later.

The transplant recipient was 57-year-old Jim Parsons who was kept alive on a ventilator after a bike accident, and the researchers have decided to call the procedure the Parsons Model.

The results demonstrate how this kind of transplantation from one species to another, known as xenotransplantation, could address a global organ shortage, the study’s lead surgeon, Dr Jayme Locke, said.

The concept of being able to have an organ waiting on the shelf, waiting for the person who needs it, is just remarkable to think about, and exciting for that person

Dr Jayme Locke

Dr Locke, director of the Comprehensive Transplant Institute in the UAB’s Department of Surgery, added: “This game-changing moment in the history of medicine represents a paradigm shift and a major milestone in the field of xenotransplantation, which is arguably the best solution to the organ shortage crisis.

“We have bridged critical knowledge gaps and obtained the safety and feasibility data necessary to begin a clinical trial in living humans with end-stage kidney failure disease.”

She added: “The concept of being able to have an organ waiting on the shelf, waiting for the person who needs it, is just remarkable to think about – and exciting for that person.”

Selwyn Vickers, dean of the UAB Heersink School of Medicine and chief executive of the UAB Health System and UAB/Ascension St Vincent’s Alliance, said: “Today’s results are a remarkable achievement for humanity and advance xenotransplant into the clinical realm.”

Since the early 2000s, researchers have tried many times to genetically modify pigs through changes that reduce the chance of the transplant being rejected.

Some 10 genes were changed in this latest donor pig. Four were disabled pig genes, also known as knockouts, and six were human genes that were cloned into the pigs, also known as knock-ins.

The human genes were added to the pig with the aim of helping to prevent rejection, both immediately and months or years down the line.

The natural lifespan of a pig is 30 years, they are easily bred, and can have organs of similar size to humans.

The procedure was conducted in much the same way that a human kidney transplant is carried out and, before the surgery, the brain-dead recipient and donor animal even underwent a crossmatch compatibility test to see if they were a good tissue match.

The pig kidneys were placed in the exact anatomic locations used for human donor kidneys, with the same attachments to the renal artery, renal vein and the ureter that carries urine from the kidney to the bladder.

The human recipient received standard immune-suppression therapy used in human-to-human kidney transplants.

The pig kidneys are prepared on the backbench (Jeff Myers/UAB)
The pig kidneys are prepared on the backbench (Jeff Myers/UAB)

Mr Parsons was a registered organ donor through Legacy of Hope, Alabama’s organ procurement organisation, but after his death his organs were not suitable for donation.

His family allowed the UAB to keep him on a ventilator to keep his body functioning during the study.

Mr Parsons’s ex-wife, Julie O’Hara, said: “Jim would have wanted to save as many people as he could with his death, and if he knew he could potentially save thousands and thousands of people by doing this, he would have had no hesitation.

“Our dream is that no other person dies waiting for a kidney, and we know that Jim is very proud that his death could potentially bring so much hope to others.”

In the US, the wait for a deceased donor kidney can be as long as five years and, in many states, it is closer to a decade. Almost 5,000 people per year die waiting for a kidney transplant.

In the UK, more than 68,000 people are being treated for kidney failure, according to the charity Kidney Care UK.

Around 3,000 kidney transplants take place annually but approximately 5,000 people are still waiting.

The average wait for a transplant is about two-and-a-half years, and every day one patient will die while waiting.

The new study is published in the American Journal of Transplantation.

It comes weeks after medics in the US made history when they transplanted a pig heart into a human patient with terminal heart disease.

The animal had also been genetically engineered so its organs could survive in a human body.

Fiona Loud, policy director at Kidney Care UK, told the PA news agency: “Right now thousands of kidney patients in the UK are waiting for the life-changing call of a transplant, so novel studies like this give a lot of hope, particularly to people who have been waiting years.

“We need to keep perspective on such developments as there have been many abandoned studies over the years.

“This one may present something more substantial because of developments in gene technology.”

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