Following a coronavirus outbreak at League Two club Orient, the game is expected to be cancelled with Spurs awarded a bye to the next round - but The O's are still hoping the fixture can be rescheduled.
Date, time and venue
Leyton Orient vs Tottenham is scheduled for a 6pm BST kick-off on Tuesday, September 22.
This match will be played behind closed doors at Orient's Breyer Group Stadium with no fans due to be present due to government guidelines regarding coronavirus.
How to watch
TV channel: The match will be televised on Sky Sports Main Event and Sky Sports Football, with coverage starting from 5.30 pm.
Live stream: Sky Sports subscribers will be able to stream the match online via the website and SkyGo app.
Jose Mourinho is expected to make a number of changes with his side to play in Macedonia on Thursday and against Newcastle on Sunday.
Tottenham have only two long-term absentees, with Japhet Tanganga still out with a thigh problem, while new signing Gareth Bale won't be available until mid-October.
After being left out of Tottenham's previous two matchday squads, Mourinho has confirmed Dele Alli will play against Orient.
“I had on the bench; Bergwijn, Lo Celso, Sissoko, Lamela… to have Dele, I need to leave somebody else behind," he said of Alli's omission from the squad that faced Southampton.
“And that’s the situation at this moment. He will play Tuesday, he needs to show how good he is.”
Alli will likely be joined by Joe Hart - who looks set to be handed his debut - while there's a possibility new signing Sergio Reguilon could feature.
It's perhaps more likely that Dennis Cirkin will be given an opportunity at left-back, however, while Toby Alderweireld, Serge Aurier, Moussa Sissoko, Erik Lamela, Ryan Sessegnon and Steven Bergwijn will likely all be involved.
Prediction: Leyton Orient 0-3 Tottenham
Though Tottenham are set to field a significantly changed side, they should still have far too much quality for their League Two counterparts.
That hostile, intimidating crowd factor you get in these special cup ties will be somewhat diminished, and I believe Tottenham will stroll to the fourth round on Tuesday.
Head to head (h2h) history and results
This will be only the 15th meeting between these two sides and, as you'd expect, it's Tottenham who come in with a significantly better record.
The north London side have won on 10 occasions, while Orient have nicked two wins, alongside three draws.
The last time the two met was back in 2001, again at the Breyer Group Stadium, where Tottenham ran out 1-0 winners in the FA Cup.
Betting odds and tips
- Orient to win: 7/1
- Tottenham to win: 40/85
- Draw: 4/1
Odds courtesy of Betfair Exchange. Click here to find out more.
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