The Reds made hard work of their group, despite being drawn against the collective weakest according to coefficients, but brushed Spartak Moscow aside on Wednesday evening.
It leaves Chelsea as the only of five Premier League representatives in the Pot Two of the knockout stage draw.
Standard Sport runs you through the permutations for Klopp's side…
Pots and seedings
As the winner of Group E, Liverpool know they will be pitted against one of the group runner-ups from Pot Two.
But with their own defensive woes already in this competition, there are still many big fishes to avoid.
Because no side can play another from the same country in the round of 16, Liverpool will not be drawn against Chelsea. They will also not face another two games against fellow Group E qualifier Sevilla.
That still leaves Klopp’s side with some daunting prospects...
Who Liverpool could face…
The might of Paris Saint-Germain and Barcelona and Tottenham's fine European form leave big guns Bayern Munich, Juventus and Real Madrid in Pot Two, which will all prove very tough tests for Klopp and his defence.
When is the draw?
The draw will take place at Uefa headquarters in Nyon, Switzerland on Monday, December 11. The draw is set to get underway at 11am GMT, and you can follow it LIVE on Standard Sport.