The Spanish side travel to Anfield with the Reds knowing a win will seal their qualification for the last-16 after only four games.
What starting XI Klopp chooses to put out will be influenced by Saturday’s surprise draw at home to Brighton, which came after Liverpool put themselves two goals up at home.
Therefore the manager may call upon returning midfielders Thiago and Fabinho after confirming their availability. However, Naby Keita and James Milner (both hamstring) remain absent along with Harvey Elliott (ankle).
Speaking about potential qualification, Klopp said: "It would be big. We usually have a 'final' in the group, the last match day, where we have to win 1-0 and the opponent is not allowed to score at all - but I hope that doesn't happen this year,.
"Of course we want to avoid that, but we can't take the second step before the first step. We just have to win, and then afterwards we can talk about what kind of achievement that would be."
Liverpool XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Tsimikas; Fabinho, Henderson, Oxlade-Chamberlain; Mane, Jota, Salah.
Subs: Adrian, Kelleher, Konate, Thiago, Firmino, Minamino, Robertson, Origi, Phillips, Williams, Morton.
Atletico XI: Oblak; Trippier, Felipe, Gimenez, Hermoso; Correa, De Paul, Koke, Carrasco; Suarez, Joao Felix.
Subs: Lecomte, Iturbe, Lodi, Vrsaljko, Herrera, Gonzalez, Serrano, Carlos, Cunha.