The victim, aged 21, was found fatally wounded by a group of four men who got out of a VW Golf after catching up to him in Waterman Court, Cippenham at 9pm on Sunday.
Thames Valley Police detectives launched a murder investigation and are hunting the men who fled the scene in the black car that could be damaged by the collision.
A police spokesman said: “Officers attended the scene where it was established that a 21-year-old man had been in a collision on his bicycle with a car, believed to be a black Volkswagen Golf in Earls Lane.
“After the collision, approximately four males exited the Golf and chased the male into Waterman Court where he was fatally attacked. The offenders then left the scene in the black VW Golf.
“Paramedics from the South Central Ambulance Service also attended, but tragically, the man was pronounced dead at the scene shortly after 9.45pm.
“His next of kin have been informed and are being supported by specially trained officers.”
Senior investigating officer, DCI Andy Howard added: “This is a tragic and shocking incident, which has resulted in the death of a 21-year -old man.
“Details at this very early stage are limited, including descriptions of the offenders.
“It is therefore incredibly important that we hear from anyone who witnessed any part of this incident. If you saw the offence itself, or if you saw a black VW Golf driving in the area prior to or after the incident, please get in touch.
“The vehicle may well have damage as a result of the collision. We would be particularly interested in hearing from anyone who has dash-cam, CCTV or doorbell footage which could be relevant.”
If you have any information that you think could help police call 101, quoting reference number 20221002-1905.