It comes after officers responded to reports of a dispute between eight men on Butchers Road on April 28, during which the victim was struck by a vehicle.
The injured man was treated at the scene before he was taken to a nearby hospital where his condition was described as critical.
But despite medics’ best efforts and treatment throughout the week, he died from his injuries on Saturday.
Next of kin have been made aware and continue to be supported by specially-trained officers.
Five males were arrested in connection with the incident and taken to an east London police station - they are currently released on bail pending further enquiries.
Police have recognised that the incident is in “close proximity” with the murder of a teenager at Coolfin Road on April 26 but they said the two are not linked and the altercation in Butchers Road was isolated.
But in response to the events, which they believe has raised concerns in the borough, residents of Newham will still see enhanced high visibility patrols from Safer Neighbourhoods officers and the Violence Suppression Unit.
Safer Schools officers will also be patrolling and engaging with the schools and colleges in the area, with additional support from the Violent Crime Taskforce and other central units.
Detective Inspector Daniel Thompson, of North East Command, which covers Newham, said: “Detectives and specially-trained officers have been working at the location of the offence throughout this week at what has been an extensive and complex crime scene. I want to thank the public for their patience whilst we conduct our enquiries.
“In response to the events of the last week, residents of Newham will see enhanced high visibility patrols from Safer Neighbourhoods officers and the Violence Suppression Unit.
Anyone who has information relating to violent crime or those who carry weapons should call police on 101 or Tweet @MetCC. To remain 100% anonymous call Crimestoppers on 0800 555 111.