Dan James comes in for the 18-year-old with Paul Pogba also in the starting XI.
Timothy Fosu-Mensah starts at right-back with Aaron Wan-Bissaka also among the subs against his former side.
Eze Eberechi and Michy Batshuayi are named among the Crystal Palace subs with Jordan Ayew starting after scoring the winner in this fixture last season.
Manchester United starting XI: De Gea, Fosu-Mensah, Lindelof, Maguire, Shaw, Pogba, McTominay, Rashford, Bruno Fernandes, James, Martial.
Subs: Bailly, Greenwood, Fred, Ighalo, Henderson, Wan Bissaka, van de Beek.
Crystal Palace starting XI: Guaita, Ward, Kouyate, Sakho, Mitchell, Townsend, McArthur, McCarthy, Schlupp, Zaha, Ayew.
Subs: Milivojevic, Meyer, Hennessey, Batshuayi, Eze, Inniss, Kelly.