The Eagles are six points above the relegation zone with three to play, and will be wary of the form shown by drop rivals Swansea given Sam Allardyce's men also face a trip to Manchester United on the final day.
Palace have already beaten Chelsea, Arsenal and Liverpool in recent weeks, and a shock win at City will all-but secure their place in the top flight for a fourth-straight season.
But City face a battle of their own to make the top four with United and Arsenal breathing down their necks.
Scroll down for Standard Sport's comprehensive preview...
Manchester City host Crystal Palace at Etihad Stadium, with kick-off scheduled for 12.30pm on Saturday May 6th.
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Palace could still be without Scott Dann and James Tomkins, while Mamadou Sakho will miss the game at City.
Yohan Cabaye is likely to return to the starting XI after being rested.
David Silva and John Stones are doubts after missing Sunday's game against Middlesbrough, while Fabian Delph could miss out after picking up a knock at the Riverside Stadium.
Yaya Toure will likely return after being rested against Boro.
Manchester City XI: Caballero, Zabaleta, Kompany, Otamendi, Clichy, Fernandinho, Toure, De Bruyne, Sane, Aguero, Gabriel Jesus
Crystal Palace XI: Hennessey, Ward, Kelly, Delaney, Van Aanholt, Milivojevic, Cabaye, Zaha, Puncheon, Townsend, Benteke
BETTING ODDS (via 888Sport)
- Manchester City to win: 1/4
- Crystal Palace to win: 19/2
- Draw: 23/4
Click here to place a bet. Odds correct as of May 3 at 9pm.