Confirmation of Manchester City's Uefa ban being overturned means it is back to a top-four race, rather than a previously-hoped top five.
However, a 96th-minute equaliser from Michael Obafemi secured the Saints a late point to keep United fifth in the table.
- GOAL! Obafemi scores late leveller
- GOAL! Martial puts United 2-1 up
- GOAL! Rashford makes it 1-1
- GOAL! Armstrong, 1-0 Southampton
- Big miss by Martial!
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How to watch
TV channel: Manchester United vs Southampton will be shown live on Sky One as well as Sky Sports' Premier League and Main Event channels, and is available via Now TV with a day pass for £9.99, or a three-month pass on offer for £25.
The game is also set to be broadcast free-to-air on Pick (Freeview channel 11).
Live stream: Sky Sports subscribers can stream the match online via SkyGo and the SkyGo app, with a mobile month pass available for £5.99.
Man Utd XI: De Gea, Wan Bissaka, Lindelof, Maguire, Shaw, Pogba, Matic, Greenwood, Bruno Fernandes, Rashford, Martial
Subs: Bailly, Mata, Andreas Pereira, Fred, James, Romero, Ighalo, McTominay, Williams.
Southampton XI: McCarthy, Walker-Peters, Stephens, Bednarek, Bertrand, Armstrong, Ward-Prowse, Romeu, Redmond, Ings, Adams
Subs: Vestergaard, Long, Obafemi, Hojbjerg, Smallbone, Gunn, Vokins, Danso, Ferry
Referee: Chris Kavanagh (Lancashire)
Prediction: Manchester United 3-1 Southampton
It would take a very brave person indeed to opt against United in their current mood.
The Red Devils have looked irresistible of late, with Solskjaer's only gripe that they aren't scoring five or six times per match.
On a three-game unbeaten run, Southampton recently showed they are capable of pulling off big results with a 1-0 win over Manchester City, while their away form is generally impressive.
However, a home win is surely the smart call here.
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