Ole Gunnar Solskjaer's side have shown title-challenging form since the restart, winning five games on the spin with an aggregate score of 16-3, extending their unbeaten run to 17 matches with a 3-0 victory over Aston Villa on Thursday.
The trio of Bruno Fernandes, Paul Pogba and Mason Greenwood have been almost untouchable - and defeats for Chelsea and Leicester at the weekend offer United a golden opportunity to go third with a win.
Now United come up against a Southampton side who are mathematically safe following an impressive three-match unbeaten run, with Danny Ings just three goals behind Jamie Vardy in the race for the Golden Boot.
Date, time and venue
Manchester United vs Southampton is scheduled for an 8pm BST kick-off on Monday, July 13, 2020.
The match will be behind closed doors at Old Trafford with no fans due to be present due to government guidelines regarding coronavirus.
How to watch
TV channel: Manchester United vs Southampton will be shown live on Sky One as well as Sky Sports' Premier League and Main Event channels, and is available via Now TV with a day pass for £9.99, or a three-month pass on offer for £25.
The game is also set to be broadcast free-to-air on Pick (Freeview channel 11).
Live stream: Sky Sports subscribers can stream the match online via SkyGo and the SkyGo app, with a mobile month pass available for £5.99.
United are blessed with an almost entirely clean bill of health at present, with only defenders Phil Jones and Axel Tuanzebe sidelined.
Meanwhile, Southampton remain without the likes of Sofiane Boufal, Yan Valery, Nathan Tella and Moussa Djenepo.
Defender Jannik Vestergaard faces a late fitness test.
Prediction: Manchester United 3-1 Southampton
It would take a very brave person indeed to pick against Manchester United in their current mood.
The Reds have looked simply irresistible of late, with Solskjaer's only gripe that they aren't scoring five or six times per match.
On a three-game unbeaten run, Southampton recently showed they are capable of pulling off big results with a 1-0 win over Manchester City, while their away form is generally impressive.
However, a comfortable home triumph is surely the smart call here.
Head to head (h2h) history and results
United have won 26 of the previous 41 Premier League meetings between these two sides, with Southampton claiming seven victories to go along with eight draws.
Vestergaard's second-half header earned the Saints a share of the spoils at St Mary's back in August after Daniel James' stylish opener and a red card for Kevin Danso.
Betting odds and tips
- Man United to win: 1/3
- Southampton to win: Between 10/1 and 11/1
- Draw: 5/1
- Over 3.5 goals: 8/5
Odds courtesy of Betfair Exchange. Click here to find out more.
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