With Marcus Rashford suspended, there was the potential to play him on the right, but Jesse Lingard gets the nod instead.
If Martial is seen as back up to Sanchez then it promises to be a frustrating season.
Antonio Valencia is back in for Diogo Dalot, who was so impressive against Young Boys, and Marouane Fellaini plays in place of the suspended Nemanja Matic.
Man Utd XI: de Gea, Valencia, Smalling, Lindelof, Shaw, Pogba, Fellaini, Fred, Lingard, Lukaku, Sanchez
Subs: Bailly, Mata, Martial, Andreas Pereira, Young, Romero, McTominay
Wolves XI: Rui Patricio, Bennett, Coady, Boly, Doherty, Joao Moutinho, Neves, Jonny, Helder Costa, Jota, Jimenez
Subs: Gibbs-White, John Ruddy, Saiss, Ruben Vinagre, Hause, Leo Bonatini, Traore
Referee: Kevin Friend (Leicestershire)