Maguire sustained ankle ligament damage during United’s 3-1 win at Aston Villa on May 9, and has been sidelined since.
The centre-back missed United’s final game of the season at Wolves on Sunday, and manager Ole Gunnar Solskjaer offered a realistic assessment that he was unlikely to be ready to play against Villarreal in Gdansk this evening.
Maguire was expected to likely try and take some part in the final pre-match training session on Tuesday night, but he ended up sitting out. He is on the bench tonight, but it remains to be seen whether or not he is fit to feature at all.
Eric Bailly will partner Victor Lindelof at centre-back, with Aaron Wan-Bissaka and Luke Shaw at full-back.
In goal, Dean Henderson has become the No1 goalkeeper meaning David De Gea has taken on cup duties, so the Spaniard starts here.
In midfield, Scott McTominay was a slight doubt but is fit to start and he’s joined in the middle by Paul Pogba, rather than regular partner Fred.
Further ahead, Bruno Fernandes, Marcus Rashford and Mason Greenwood all start in support of Edinson Cavani in what looks an attacking line-up.
Man Utd starting lineup(4-2-3-1): De Gea, Wan-Bissaka, Lindelof, Bailly, Shaw, McTominay, Pogba, Fernandes, Greenwood, Rashford, Cavani
Injury list: Jones, Martial
Man Utd Europa League squad
Goalkeepers: David De Gea, Dean Henderson, Lee Grant, Nathan Bishop
Defenders: Eric Bailly, Victor Lindelof, Harry Maguire, Luke Shaw, Alex Telles, Axel Tuanzebe, Aaron Wan-Bissaka, Brandon Williams
Midfielders: Amad, Bruno Fernandes, Fred, Daniel James, Juan Mata, Nemanja Matic, Scott McTominay, Paul Pogba, Donny van de Beek
Forwards: Edinson Cavani, Anthony Elanga, Mason Greenwood, Marcus Rashford, Shola Shoretire