The veteran eight-division world champion confirmed with a promotional poster released on social media on Friday night that the high-profile bout would take place on August 21 in Las Vegas, Nevada.
Boxing icon Pacquiao turns 43 in December though still appears keen for big fights, with formidable 147-pound king Spence Jr currently the unified WBC and IBF welterweight champion.
‘Pac-Man’ will be fighting for the first time in more than two years, having become the oldest welterweight champion in history by outpointing the previously unbeaten Keith Thurman in July 2019.
He defeated Adrien Broner earlier that year and also stopped Lucas Matthysse in seven rounds in Malaysia in July 2018 - his first fight following a hugely controversial defeat by Jeff Horn in their world title clash in Brisbane in the summer of 2017.
A two-fight deal with Mikey Garcia collapsed in 2020 due to the Covid-19 pandemic and talks with the likes of Ryan Garcia and Terence Crawford have not had the desired outcome, while UFC superstar Conor McGregor previously said that he expected to return to boxing this year to take on Pacquiao.
A meeting with Spence Jr represents an enormous challenge for Pacquiao, who boasts a professional record of 62-7-2 from 71 fights.
‘The Truth’ is regarded as one of the world’s very finest pound-for-pound fighters and boasts an unblemished pro record of 27-0, with 21 knockouts.
Spence Jr has been a world champion since defeating Britain’s Kell Brook to claim the IBF title in May 2017 and retained it three times against Lamont Peterson, Carlos Ocampo and Mikey Garcia before adding the WBC strap with a dramatic split-decision win over Shawn Porter in September 2019.
Following a serious car accident in Dallas that threatened to derail his illustrious career, the 31-year-old returned to action in December and successfully defended his belts in a dominant win over Danny Garcia.