The Filipino was back to his best with speed and combinations enough to hand 'One Time' his first loss of his career.
The division is wide open now, with Pacquiao set to face the winner of Errol Spence Jr vs Shawn Porter. Re-live the live action below.
"I’m just blessed tonight, he’s not an easy opponent. I think next year, I have to go back to the Philippines to work (as a senator)," Pacquiao says.
"Yes, I hope I can be there to watch that fight."
"Pacquiao is a truly great champion," says Thurman.
"I wish I had a bit more output to go toe-to-toe.
"It was just behind Manny Pacquiao. I want the rematch.
"It was a blessing and a lesson."