Tributes are being paid to the "beyond iconic" Margaret Nolan, who starred in Goldfinger and danced as the gold-painted model in the film's title sequence, following her death at the age of 76.
Dangerously ill coronavirus patients are making "startling recoveries" in spite of being at "death's door" after being given drugs that dial down the immune system, experts have said. Trials are taking place of several drugs that prevent a part of the immune system called the complement system from becoming over-activated. The drug furthest along in trials, ravulizumab, is already used to treat rare blood diseases and is being tested at hospitals in Cambridge, London, Birmingham and Leeds. The drugs are known as "anti-C5" drugs because they prevent a molecule called C5 from triggering the complement-system response. Speaking at a coronavirus briefing on Thursday, Professor Paul Morgan, the director of the Systems Immunity Research Institute at Cardiff University, said the drugs were providing a lifeline for patients who were near death. He said: "Switching off C5 can have a big effect. We and others have used anti-C5 blocking agents in small scales on very severe Covid patients with very promising results. "These were people who had reached the stage where there was no further therapy for them; they were on ventilators, and really at death's door ... [some] have made startling recoveries. "Of course these are small numbers, but these drugs are now in large scale clinical trials and we want to see the outcomes of those in the too distant future." The complement system helps clear away harmful cells and triggers the production of immune cells known as cytokines which can cause inflammation. However, when in overdrive it begins attacking the body itself and is thought to play a role in many autoimmune diseases, including asthma, arthritis, multiple sclerosis and inflammatory bowel disease. It is also the response that causes sepsis. In the early stages of the disease, Covid-19 is believed to switch off the body's ability to make the anti-viral proteins called interferons. It is the reason patients do not feel unwell even when they have a lot of virus in the body. Although anti-viral drugs such as remdesivir have not proved as successful as hoped in trials, it is possible they may work earlier in the illness to stop the immune system from overloading. Paul Lehner, professor of immunology and medicine at the University of Cambridge, said it was crucial to try and treat the disease before the dangerous immune storm had happened. "We have to get better at asymptotic screening and we need to treat those at risk early," he said. "We are identifying now, I think, good and better inhaled antiviral agents. We've got to learn how to treat early to avoid the severe stage disease. Inhaled interferons or remdesivir may be effective in the early stage." Professor Sir Stephen O'Rahilly, the director of the MRC Metabolic Diseases Unit at the University of Cambridge, also said people could help themselves by losing weight. Sir Stephen, who caught coronavirus in the spring, believes he only survived because he had lost 13 pounds in the preceding months and said: "Even a small amount of weight loss can be beneficial. Walk a mile, lose a pound. Even a modest degree of calorific restriction in a matter of days can start to shift fat in the organs even before body weight reduces. "We might be able to accelerate this with diabetes drugs, using them in people who don't have diabetes, to improve insulin sensitivity."
Covid surge 'very serious' in Germany and 'out of control' in Spain. Czech PM apologises for bringing back tough measures; Poland and Croatia set daily records
Veteran journalist Martin Bashir is "seriously unwell" with coronavirus-related complications, the BBC has said. The 57-year-old, best known for his 1995 interview with Diana, Princess of Wales, currently works as the BBC News religion editor. A spokeswoman for the BBC said: "We are sorry to say that Martin is seriously unwell with Covid-19 related complications. "Everyone at the BBC is wishing him a full recovery. "We'd ask that his privacy, and that of his family, is respected at this time." Bashir began working as a journalist in 1986 but made headlines around the world in 1995 for his BBC interview with Diana, Princess of Wales for Panorama. That interview has seen renewed interest in the lead up to a new Channel 4 film, which examines the circumstances behind their meeting, airing on Wednesday night. Bashir's other high-profile interviews have included the suspects in the Stephen Lawrence murder case, entertainer Michael Barrymore, Jeffrey Archer and Major Charles Ingram, dubbed "the coughing major". In 2003, he conducted a series of interviews with pop singer Michael Jackson for the controversial ITV documentary Living With Michael Jackson. He later moved to the US where he co-anchored the current affairs show Nightline on ABC before moving to MSNBC, where he served as a political commentator until 2013. He subsequently returned to the BBC as the broadcaster's religion editor. October 2019 saw him compete in the celebrity spin-off of X Factor.
‘There must be accountability for the lying and deaths — this is just the start,’ says anti-Trump conservative group
The total of 101,494 new infections is the highest since NHS Test and Trace was launched in May.
Nasa is to announce an “exciting” new discovery about the moon.The space agency revealed few details of the discovery but said it “contributes to NASA’s efforts to learn about the Moon in support of deep space exploration.”
From masks to herd immunity and "false positives", these people have spread potentially dangerous disinformation to hundreds of thousands of people.
Even a prince would sweat at that kind of grilling. For seven hours over the course of two days, Ghislaine Maxwell was interrogated, probed and prodded over everything from sex toys in a laundry basket to whether Jeffrey Epstein, a convicted paedophile, had ever had sex with a child. On the subject of the Duke of York, Ms Maxwell gave the Queen's son her backing. The prince famously told Newsnight that allegations he had slept with Virginia Roberts Giuffre when she was a teenager were false, not least because he didn't sweat, but Ms Maxwell came up with a different explanation for why the sex didn't take place – her bathtub was too small. Ms Maxwell had fought hard to keep the deposition, given in April 2016 in response to a defamation claim brought by Ms Roberts Giuffre, out of the public domain. However, on Thursday, on the orders of a New York judge, all 417 pages were unsealed – most of it unsavoury, often lurid accusations, followed by Ms Maxwell's ever-angrier denials.
Tax was not paid on two properties for 18 years because they never had planning permission.
The Maldives, Canary Islands, Mykonos and Denmark have been removed from the UK's quarantine list. Lichtenstein is the only country to lose its quarantine exemption this week - starting from the same date and time.
Much unlike a scrunchie, hair clip, or even a hat, a shower cap is one of those hair accessories of which many of us overlook the benefits. Sure, most people use them to prevent their hair from getting wet in the shower - after all, that's how they're marketed - but there are actually a few other reasons why you should invest in a reusable shower cap that you'll always be able to rely on. Outside of helping you conserve water and energy by skipping the shampoo process, wearing a shower cap can help you protect and preserve the hairstyle you're currently wearing, especially if you've recently gotten a blowout or if you've had your hair professionally straightened. Covering it with a quality cap will keep out moisture that can cause frizz that may later lead you to have to re-style your hair. They're also beneficial when it comes to sealing moisture into the hair, which is why plenty of people use them while deep conditioning; they can help trap the heat being released from the top of your head and can keep your hair's cuticles open so that the hydrating ingredients can more easily penetrate. Are you sold yet? If so, do away with your single-use, plastic shower caps and shop a few of our favorite reusable (and fashion-forward) ones ahead.
Nadine Dorries told MPs she is "no longer immune" to coronavirus as she rejected the notion that there can be herd immunity without a vaccine.The health minister, 62, was the first MP to be diagnosed with Covid-19 in March.
Anne Sacoolas’s lawyers previously admitted she was driving on the wrong side of the road before the crash in Northamptonshire in August last year.
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Presley spoke on what would have been Keough’s 28th birthday
China threatened on Thursday to retaliate against the latest U.S. arms sale to Chinese-claimed Taiwan, as the island welcomed the weapons package but said it was not looking to get into an arms race with Beijing. The Trump administration has ramped up support for Taiwan through arms sales and visits by senior U.S officials, adding to tensions between Beijing and Washington, already heightened by disagreements over the South China Sea, Hong Kong, human rights and trade. Beijing has applied increasing pressure on democratically-ruled Taiwan to accept China's sovereignty, including by flying fighter jets across the sensitive mid-line of the Taiwan Strait, which normally serves as an unofficial buffer.
Footage from the Met's Operation Trigona: an undercover investigation to identify organised criminal networks involved in Class A drug supply in London. The arrests follow a long-running operation which saw officers carry out a number of early morning raids in London, Kent and the Thames Valley over the last six weeks.