Spurs cut Chelsea's lead at the top of the table to four points with a 4-0 victory against Bournemouth ahead of the Blues' trip to Manchester United on Sunday.
Antonio Conte's side have led the way since November 5, but Pochettino expects Chelsea to feel the title pressure at Old Trafford following Tottenham's win.
The 4-0 victory over Bournemouth was Spurs' second in succession by that scoreline after they dispatched Watford at White Hart Late last Saturday.
And Pochettino believes Tottenham's relentless attacking approach could shift the shape of things at the top of the Premier League.
Asked if goal difference could be a factor in the title race, Pochettino said: "For me, yes. And for them, too.
"It's so important. The only way to build that winning mentality is to always play in the same tempo and with the same focus and concentrations during 90, 95 minutes.
"Never give up. 3-0, 4-0 or 1-0, 2-0 – the team must forget the result. It's important to always try to go forward, keep possession, score goals – that is the mentality that we are building in the group."