Sean Dyche's side are languishing in 13th place in the Premier League table but boast the sixth best home record in the division, having amassed 29 points from 14 top-flight games.
The Clarets have dropped points in front of their home fans on just five occasions this term and secured a creditable draw against pacesetters Chelsea last time out.
Spurs have failed to win on their travels since victory over Watford on New Year's Day and Pochettino is adamant his players must come flying out of the blocks to ensure they do not fall victim to an upset.
“It will be tough," Pochettino said of his side's trip to Lancashire.
"They are doing very well at home and we know very well that we need to fight from the first moment in the game.
"They are a very physical team, a very aggressive team and it will be tough. Not only must we give our best, we must be ready to fight for every single ball.”
Pochettino - like many Premier League managers - has been unable to work with the majority of his squad during the international break.
Tottenham's players have been representing their respective nations across the globe and only returned to Hotspur Way for training today [Thursday].
Such a short amount of time to prepare for a crucial away day is far from ideal but Pochettino is adamant the north Londoners most focus on the task at hand rather than any potential excuses.
“It’s always difficult for a club like us because nearly all the players were involved with their national teams.
"It’s always tough, it’s only a few players training and always it’s so difficult to keep the motivation
"It’s not too much time to prepare for the game but that is the competition, we need to accept that and we need to be ready to compete," Pochettino added.
Meanwhile, the game will come too soon for injured striker Harry Kane but Spurs are upbeat about the 23-year-old's return to action.