More than 13,000 people are set to receive an extra £150 to help cope with the cost-of-living crisis.
Those receiving disability benefits in Blackburn are set to receive the payment from this week.
The government say that those living with a disability are facing some of the worst impacts of the cost-of-living crisis, having more care and mobility needs than the general population.
The Department of Work and Pensions estimates that 13,100 individuals in Blackburn can expect the payment, with the Government saying that the vast majority of those eligible will have received it by the start of October.
Those who already receive a qualifying disability benefit will be paid automatically, the Government has said.
The new Chancellor, Kwasi Kwarteng, described the scheme as "providing vital support to shield the most vulnerable".
The payment comes in addition to a plan announced by Prime Minister Liz Truss on September 8 to freeze energy bills at £2,500 for the next two years.
This week’s payment is separate from the £650 cost-of-living payment, the first instalment of which landed over the summer.
In total, the DWP estimates around 6.3million people are eligible for the disability payment across Great Britain – including 820,000 in the North West.
Those eligible for the payment include people who on May 25 were receiving the disability living allowance, personal independence payment, attendance allowance, armed forces independence payment, constant attendance allowance, or the war pension mobility supplement.
People are also being urged to be alert to scammers targeting those expecting cost-of-living payments.
Work and Pensions Secretary Chloe Smith said: "We know disabled people face additional costs, and this government is listening and taking decisive action to protect the most vulnerable in our society.
"This multi-billion-pound package of support reinforces our commitment to help UK households, particularly those with disability challenges, through the tough times ahead."