Police say they believe the victim was attacked by up to three men, and are appealing for witnesses to come forward.
Police and paramedics were called at 11.50pm on Friday to a report of a man stabbed in Bromley Road.
They found the victim suffering stab injuries. He was taken to hospital for treatment but tragically died during Saturday afternoon.
Police believe they know the identity of the deceased and his next of kin have been informed, though formal identification is yet to take place.
Detective Chief Inspector Kelly Allen from the Met’s Specialist Crime Command, who is leading the investigation, appealed for witnesses to come forward following “another senseless loss of life to knife violence”.
“We know there were several people in the Bromley Road area who either witnessed this incident or the events leading up to and after this incident,” she said.
“I would urge them, along with any road users in the area who may have captured events on dashcam to come forward and speak to police.
“At this early stage we believe the victim was attacked by up to three men, who then fled the scene on foot.
“A young man’s family is grieving following another senseless loss of life to knife violence; please help them get justice and speak to police if you know anything that could help us.”
There has been no arrest and enquiries into the circumstances continue.
Anyone with information or any witnesses who are yet to speak with police are asked to call 101, ref 8645/4Nov. To remain anonymous, please contact the independent charity Crimestoppers on 0800 555 111.