The Baja California Department of Culture said Friday that Raymundo Garduño Cruz and Juan Francisco González Aguilar died in the crash on Thursday near the city of Mulege.
Local media reported that the crash occurred on Thursday, and said the van flipped after running off the road in a desert area.
Six other members of the cast and crew were injured but remain stable, Netflix said.
The crew had apparently been working in the nearby Santa Rosalia area at the time.
The Netflix series is described by the streaming platform as: “A 12-year-old boy learns he’s the returned Jesus Christ, destined to save humankind. Based on the comic book series by Mark Millar and Peter Gross.”
Production for the upcoming series had begun in April, according to Comicbook.
No release date had been made public for the series.
The series is not to be confused with Netflix’s other series named The Chosen One, which originally aired in 2019 and has run for two seasons.
A Netflix spokesperson said: “We’re sad to confirm that two cast members have passed away after a tragic accident in transit from Santa Rosalía to the local airport.
“Two other cast members and four crew members were injured but remain stable. Investigations are ongoing on the reasons for the accident, and production was paused for a few days out of respect for the victims. Our thoughts are with them and their family at this time.”