One person has been killed and 10 people injured in a nine-vehicle pile-up on the M6 in Cheshire.
The crash on the southbound carriageway between junctions 17 and 16 involved two lorries, five cars and two vans.
A spokesman for Cheshire Fire and Rescue Service said five people had to be cut from the wreckage.
The person who died was pronounced dead at the scene.
Cheshire Constabulary said two people suffered life-threatening injuries and another was seriously hurt.
The casualties were taken to hospitals in Leighton, Crewe and Stoke for treatment.
A spokesman for the Highways Agency told Sky News that the southbound M6 was likely to remain closed for several hours between junctions 18 and 16.
The northbound carriageway was closed for a time to allow the air ambulance to land and take off.