The pair will face each other in Sunday's crunch clash as leaders Chelsea visit Manchester United attempting to extend their lead at the top of the Premier League to seven points.
Kante earned a reputation for his high work-rate as he helped Leicester to the Premier League crown last term and will win a second straight league medal if Chelsea show similar stamina during the run-in.
The France international has been nominated alongside team-mate Eden Hazard for the Player of the Year award and Pogba believes Kante has made the difference for Chelsea this term as they close in on a second league crown in three seasons.
"Everybody knows that N'Golo Kante can run for 11 players – that's his best quality," Pogba told MUTV.
"He gets the ball and plays simple. When the manager tells him something, he will do it and he will do it perfectly.
"He's one of the biggest players for Chelsea. He makes the difference because, to be honest, when you see when they lose the ball, he will lose the ball three times and win the ball back four times!
"He's everywhere! He's a big player."