The band will perform a total of five consecutive shows at the London venue between October 30 and November 3.
Tickets are on sale now and can be bought here.
The shows will celebrate thirty years since the influential band formed in 1988.
The Pixies will also celebrate their 30th anniversary by releasing a delux version of their album Come On Pilgrim...it's Surfer Rosa in August.
The group last performed in London at the British Summer Time event in Hyde Park last June.
The Pixies have released six studio albums, with their most recent record Head Carrier coming in 2016. They are widely regarded as one of the greatest alternative American rock bands of all time.