Schoolboy Demetrace Nyakana was last seen at 8.20am on the Lytchett estate in Enfield walking to Carterhatch school, around a mile away.
He was wearing a Cartherhatch school uniform navy top and grey trousers.
Enfield Police tweeted for help and appealed for anyone who saw him or knows his whereabouts to contact them immediately.
A police spokesperson wrote: “Police are appealing to trace 10-year-old missing Demetrace Nyakana.
“He was last seen at 8.20am on the Lytchett Estate. Demetrace is wearing a Carterhatch school uniform, navy top and grey trousers.
“Please call the police with any sightings.”
Anyone with information is asked to call police on 101.