The 55-year-old woman was struck by the vehicle on Croftfoot Road near Rutherglen at about 6.35pm on Thursday.
Emergency services attended, but she was pronounced dead at the scene.
Sergeant Adnan Alam from Motherwell Road Policing said: “Inquiries into this incident are at an early stage.
Officers in South Lanarkshire are appealing for witnesses after a 55-year-old woman was hit by a car and killed on Croftfoot Road earlier this evening.
The incident happened around 6.35pm.
Any info please call 101 quoting incident no. 2816 of 13 Jan 22.https://t.co/HnnHFclwr0 pic.twitter.com/hfztX1lJpV
— Lanarkshire Police (@Lanarkshire_Pol) January 13, 2022
“It has happened on a busy road, and we are appealing to anyone who was in the area at the time or has dashcam footage from the scene to get in touch via 101 quoting incident reference number 2816 of January 13 2022.”