Manchester - An explosion struck an Ariana Grande concert attended by thousands of young music fans in northern England, killing at least 22 people and injuring dozens in what police said on Tuesday they suspected was a terrorist attack.
Greater Manchester Police Chief Constable Ian Hopkins says police are treating the blast as an act of terrorism "until we know otherwise". The local ambulance service says 59 people were taken to hospitals.
Manchester police say an apparent suicide bomber set off an improvised explosive device at the end of an Ariana Grande concert.
Police raised the death toll to 22 early on Tuesday, and dozens more have been reported injured.
Hopkins says forensic investigations are continuing to determine if the attacker had accomplices.
He provided no information about the individual who detonated the device. Police are trying to determine if the person acted alone or had support in the blast.
There was panic after the explosion, which struck around 22:30 on Monday night as Grande was ending the concert, part of her Dangerous Woman Tour.
The singer, who was not injured, tweeted hours later: "Broken. From the bottom of my heart, I am so so sorry. I don't have words."
Police cars, bomb-disposal units and 60 ambulances raced to the scene as the scale of the carnage became clear. More than 400 officers were deployed overnight after the blast occurred.
Manchester Arena said on its website that the blast struck outside the venue as concertgoers were leaving. Some eyewitnesses said it happened in the foyer of the arena just after the concert ended.
One witness said Grande had just finished her final song and said "Thank you, Manchester," before leaving the stage.
The incident led to a nightlong search for loved ones as frantic parents tried to locate their teenage children and groups of friends scattered by the explosion sought to find one another.
Taxi services offered to give stranded concertgoers rides home for free, and residents opened their homes to provide lodging for people who could not get home because public transport had shut down.
City officials said the true spirit of Manchester would shine through despite the horrendous incident.
Twitter and Facebook were filled with appeals for information about people who had not been accounted for.
Home Secretary Amber Rudd called the incident "a barbaric attack, deliberately targeting some of the most vulnerable in our society — young people and children out at a pop concert".
Jenny Brewster said she was leaving the concert with her 11-year-old daughter when the blast hit.
"As I turned around, boom, one loud noise," she told Sky News. "A gentleman said 'run!' so we ran."
Outside, she said, "you could smell the burning."
Britain's terrorist threat level stands at "severe," the second-highest rung on a five-point scale, meaning an attack is highly likely.
There was no immediate claim of responsibility. Supporters of the extremist Islamic State group, which holds territory in Iraq's Mosul and around its de facto capital in the Syrian city of Raqqa, celebrated the blast online. One wrote: "May they taste what the weak people in Mosul and (Raqqa) experience from their being bombed and burned," according to the US-based SITE Intelligence Group.
If the explosion is confirmed as a terrorist attack it would be the deadliest in Britain since four suicide bombers killed 52 London commuters on three subway trains and a bus in July 2005.
"A huge bomb-like bang went off that hugely panicked everyone and we were all trying to flee the arena," said concertgoer Majid Khan, 22. "It was one bang and essentially everyone from the other side of the arena where the bang was heard from suddenly came running towards us as they were trying to exit."
Added Oliver Jones, 17: "The bang echoed around the foyer of the arena and people started to run."
Video from inside the arena showed concertgoers screaming as they made their way out amid a sea of pink balloons.
WATCH A VIDEO FROM THE SCENE HERE:
British Prime Minister Theresa May said the government was working to establish "the full details of what is being treated by the police as an appalling terrorist attack."
May is due to chair a meeting of the government's COBRA emergency committee later on Tuesday. She and other candidates suspended campaigning for Britain's June 8 election after the blast.
Police advised the public to avoid the area around the Manchester Arena, and the train station near the arena, Victoria Station, was evacuated and all trains cancelled.