Putin critic Alexei Navalny has been pictured walking down stairs in hospital as he continues to recover after being poisoned with novichok.
Dangerously ill coronavirus patients are making "startling recoveries" in spite of being at "death's door" after being given drugs that dial down the immune system, experts have said. Trials are taking place of several drugs that prevent a part of the immune system called the complement system from becoming over-activated. The drug furthest along in trials, ravulizumab, is already used to treat rare blood diseases and is being tested at hospitals in Cambridge, London, Birmingham and Leeds. The drugs are known as "anti-C5" drugs because they prevent a molecule called C5 from triggering the complement-system response. Speaking at a coronavirus briefing on Thursday, Professor Paul Morgan, the director of the Systems Immunity Research Institute at Cardiff University, said the drugs were providing a lifeline for patients who were near death. He said: "Switching off C5 can have a big effect. We and others have used anti-C5 blocking agents in small scales on very severe Covid patients with very promising results. "These were people who had reached the stage where there was no further therapy for them; they were on ventilators, and really at death's door ... [some] have made startling recoveries. "Of course these are small numbers, but these drugs are now in large scale clinical trials and we want to see the outcomes of those in the too distant future." The complement system helps clear away harmful cells and triggers the production of immune cells known as cytokines which can cause inflammation. However, when in overdrive it begins attacking the body itself and is thought to play a role in many autoimmune diseases, including asthma, arthritis, multiple sclerosis and inflammatory bowel disease. It is also the response that causes sepsis. In the early stages of the disease, Covid-19 is believed to switch off the body's ability to make the anti-viral proteins called interferons. It is the reason patients do not feel unwell even when they have a lot of virus in the body. Although anti-viral drugs such as remdesivir have not proved as successful as hoped in trials, it is possible they may work earlier in the illness to stop the immune system from overloading. Paul Lehner, professor of immunology and medicine at the University of Cambridge, said it was crucial to try and treat the disease before the dangerous immune storm had happened. "We have to get better at asymptotic screening and we need to treat those at risk early," he said. "We are identifying now, I think, good and better inhaled antiviral agents. We've got to learn how to treat early to avoid the severe stage disease. Inhaled interferons or remdesivir may be effective in the early stage." Professor Sir Stephen O'Rahilly, the director of the MRC Metabolic Diseases Unit at the University of Cambridge, also said people could help themselves by losing weight. Sir Stephen, who caught coronavirus in the spring, believes he only survived because he had lost 13 pounds in the preceding months and said: "Even a small amount of weight loss can be beneficial. Walk a mile, lose a pound. Even a modest degree of calorific restriction in a matter of days can start to shift fat in the organs even before body weight reduces. "We might be able to accelerate this with diabetes drugs, using them in people who don't have diabetes, to improve insulin sensitivity."
Nasa is to announce an “exciting” new discovery about the moon.The space agency revealed few details of the discovery but said it “contributes to NASA’s efforts to learn about the Moon in support of deep space exploration.”
The total of 101,494 new infections is the highest since NHS Test and Trace was launched in May.
Anne Sacoolas’s lawyers previously admitted she was driving on the wrong side of the road before the crash in Northamptonshire in August last year.
A ‘selfless and brave’ church warden was beaten to death as he tried to stop another shopper from being stabbed, a court heard. John Rees, 88, had left his wife Eunice, 87, in their car while he went inside a village Co-op to pick up essentials in May. But he was stabbed in the face by mum-of-one Zara Anne Radcliffe, 30, when he found her attacking a nurse with a knife. Brave Mr Rees saved nurse Gaynor Saurin when he tried to tackle Radcliffe. But he was tragically stabbed himself - before Radcliffe then attacked him with a glass bottle and a fire extinguisher. Mr Rees died inside the Co-op store and three other shoppers were injured in the frenzied attack in Penygraig in the Rhondda, South Wales. Prosecutor Michael Jones QC described Mr Rees's efforts to stop Radcliffe as "A selfless and brave act which cost him his life." He added: "Another customer, Lisa Way, attempted to talk to the defendant but she was attacked and injured by the knife. "The defendant focused on Mr Rees and repeatedly attacked him with a glass wine bottle and a fire extinguisher as he laid on the floor." Church warden Mr Rees was described as "the very definition of a good man, extremely respected and liked in the community" by his family. His cause of death was recorded as severe blunt trauma to the face including multiple facial fractures. Radcliffe admitted manslaughter by diminished responsibility over the attack which happened in May. On Wednesday, she was sentenced to indefinite hospital orders under sections 37 and 41 of the Mental Health Act by a judge at Merthyr Crown Court after pleading guilty to the manslaughter by diminished responsibility.
Now a judge has ruled that jurors on the case can speak, some unsavory facts about how the case was handled have come to light
‘I’m not coming back until Amy Coney Barrett is a Supreme Court Justice,' senator says
‘I enrolled in a Covid-19 vaccine trial to show other Black people how much I believe in science,’ writes Dr Lisa Fitzpatrick
Follow the latest updates from the pandemic
The Maldives, Canary Islands, Mykonos and Denmark have been removed from the UK's quarantine list. Lichtenstein is the only country to lose its quarantine exemption this week - starting from the same date and time.
Nicola Sturgeon has been accused of sacrificing Scotland’s pubs, restaurants and thousands of jobs, after she tore up plans for a “temporary” shutdown of hospitality venues and instead left some businesses facing indefinite closure. The First Minister sparked fury from the hospitality sector after she admitted on Wednesday that a blanket closure of pubs and restaurants in the Central Belt, which she initially said would last for just 16 days, had been extended by a week because she had changed her mind. Some of the affected venues will then face further restrictions under a new five-tier lockdown system, which will come into force on November 2, immediately after the extension expires. The current rules have also meant venues in other parts of Scotland face significant curbs, with some choosing to temporary close down voluntarily.
"Barack Hussein Obama,' president says over and over as Gastonia crowd boos in unison
A man was filmed smashing wine and liquor bottles at a Tesco store in Drogheda, County Louth, Ireland, on October 21, local reports said.“A very sad day watching all the whiskey and wine gone to waste,” wrote Martin Quinn, who took this video.According to Quinn, the incident happened late morning on Wednesday.Reports said the police were investigating, and while it was unknown what provoked the man, but he “was not wearing a mask and it is though [sic] that he became upset when asked to do so.”Local reports said the man refused bail terms, which included staying away from all Tesco locations in the country and remaining sober, and was set to appear in court on October 23. A judge directed that the man receive a psychiatric evaluation, the report said. Credit: Martin Quinn via Storyful
I've always been somewhat of a gambler. In fairness, this is not entirely my fault: I was born in Las Vegas, and thereby entered into this world with an inherent propensity for all things high stakes. In that sense, it doesn't feel too off base that I left my latest haircut up to chance. Let me explain. After doing absolutely nothing with my hair but allowing it to live, unperturbed, atop my head for nine-plus (!) months, my ends were starting to look long, dry, and drab. Meanwhile, I was reporting on the most-requested hairstyles following salon reopenings amid the coronavirus pandemic - all of which were striking and chic (and the polar opposite of my own look). Itching for change but not a clue what I wanted, I booked an appointment with Robert Sherman, the lead stylist at the Frederic Fekkai Salon in NYC, with an idea: what if I let him, based on his expertise and the season's biggest trends, determine the fate of my next haircut? It would be like letting your partner decide which restaurant to take you to for your birthday. "I don't know, surprise me!" When I walked into the salon, I laid out all my cards on the table. In an attempt to alleviate any pressure to run through the exhaustive list of haircuts out there, I had narrowed it down to three of the coolest styles I've seen of late for him to choose from: the modern shag, the A-line bob, and the textured clavicut. Each one would require I chop off at least five inches of hair, if not more, but would be easy enough to style according to my low-maintenance lifestyle. Then, it was time to roll the dice. The cut he would ultimately decide on was merely the luck of the draw.
A Glasgow cafe has won a legal action that prevents authorities from forcing it to close under coronavirus rules, in what is believed to be the first successful court challenge to a shutdown of Central Belt hospitality venues. Giovanna Eusebi, Owner of Eusebi Deli in the city's affluent West End, said last night that she was "delighted" to have won an interim interdict against Glasgow City Council, which had ordered the business to stop serving customers. The business had argued that it met the legal definition of “cafe”, which are legally allowed to continue operating, under rules set out by the Scottish Government but left to town halls to enforce. Glasgow Council has adopted a hardline approach to the new restrictions, telling businesses to close on the basis that they did not meet the “spirit” of Nicola Sturgeon’s shutdown of pubs, bars and restaurants in Scotland’s Central Belt, even if they might meet the legal definition. “We are delighted by the decision of the court which vindicates the position we have taken from the very beginning,” Ms Eusebi said, following the legal victory on Tuesday afternoon, which prevents the council from serving it with a prohibition notice. “Since reopening in the summer, we have served thousands of customers in a safe and secure café and deli environment with every precaution in place. We look forward to getting back to concentrating on welcoming the people of Glasgow on that basis”.
China threatened on Thursday to retaliate against the latest U.S. arms sale to Chinese-claimed Taiwan, as the island welcomed the weapons package but said it was not looking to get into an arms race with Beijing. The Trump administration has ramped up support for Taiwan through arms sales and visits by senior U.S officials, adding to tensions between Beijing and Washington, already heightened by disagreements over the South China Sea, Hong Kong, human rights and trade. Beijing has applied increasing pressure on democratically-ruled Taiwan to accept China's sovereignty, including by flying fighter jets across the sensitive mid-line of the Taiwan Strait, which normally serves as an unofficial buffer.
The Supreme Court's deadlock this week in a key election case illustrates the power President Donald Trump's nominee Amy Coney Barrett could wield and reveals why Republicans are hurrying to install her as a justice, Democrats said on Wednesday in their latest pitch to block her U.S. Senate confirmation. Chief Justice John Roberts broke with the four other conservative justices and joined with the court's three liberals on Monday in denying a request by Republicans seeking to block a state court's ruling that extended the deadline for the delivery of mail-in ballots in Pennsylvania by three days.
Not everyone is a fan of winter weather for many reasons, one being because of the number it can do on your hair - especially if you have kinky or curly hair. Truth is, curls already have a tendency to dry out faster regardless of the season (you can thank the natural oils from your scalp, which have a harder time traveling down a spiral strand than they do straighter types, for that), so when you pair that with the cold, moisture-sucking air that tends to come in the winter months, you're bound to experience even more dryness than usual. That said, much like you might tweak your skin-care routine in the winter to make sure your skin is staying hydrated and healthy, there are also a handful of changes you can make to your hair-care regimen to ensure your curls retain as much moisture as possible. If you're currently looking for ways to winter-proof your curly hair-care routine, read ahead for a few pro tips.
Between spending so much time inside and always wearing protective masks outside, if you haven't had at least one skin flare-up this year, please keep that luck to yourself. However, if you're like most of us, you've noticed either a rise in acne, dryness, or general irritation . . . and have been switching up your routine to balance things back out. With face wash in particular, it's true that skin can also get triggered by potent formulas it's not used to, sometimes what is causing the issue isn't an active ingredient (or something you're doing), but a hidden fragrance in your products. For sensitive skin types, artificial fragrances (and colors and preservatives) can be especially irritating. That's why you might consider looking for gentle, fragrance-free options (which, to be clear, is different from unscented) to help press reset. Since we're all in this together, we picked out the best fragrance-free face cleansers at Sephora to help you get started. Each one skips the synthetic fragrance entirely so, if you smell anything, it's coming from natural ingredients (like essential oils and plant extracts) also found - and working - inside. Check out our favorite fragrance-free face wash ahead, which, even without a noticeable aroma, are all still pretty sweet.