Chuck Berry, one of the godfathers of rock n roll has died, aged 90.
Police in St Charles county, Missouri, said the singer had been found unresponsive just at 5.40pm UK time (12.40pm US Central time).
Officers tried to administer first aid but were unsuccessful.
A spokesman said: "St Charles County police responded to a medical emergency on Buckner Road at approximately 12.40 p.m. today [Saturday, March 18].
"Inside the home, first responders observed an unresponsive man and immediately administered lifesaving techniques.
"Unfortunately, the 90-year-old man could not be revived and was pronounced deceased at 1:26 p.m.
"The St Charles County Police Department sadly confirms the death of Charles Edward Anderson Berry Sr., better known as legendary musician Chuck Berry.
"The family requests privacy during this time of bereavement."
Known as the "Father of Rock 'n' Roll", Berry influenced scores of modern-day musicians and bands including the Rolling Stones' Keith Richards.
Songs including Johnny B. Goode, Maybellene and Memphis have been much covered and taught to many a budding young guitarist.
Born in St Louis in October 1926, he attempted to emulate his musical heroes including Nat King Cole and Muddy Waters.
Berry was the first black star to reach true international stardom as rhytmn and blues morphed into rock n roll, becoming an icon for his guitar style and onstage theatrical style.
Citing his influences, he said: "The main guy was Louis Jordan. I wanted to sing like Nat Cole, with lyrics like Louis Jordan with the swing of Bennie Goodman with Charlie Christian on guitar, playing Carl Hogan's riffs, with the soul of Muddy Waters."
His life was not without controversy and he was sentenced to three years in prison after transporting a 14-year-old girl across state lines.
However his place in popular music's history was never in doubt and he was among the first musicians inducted into the Rock and Roll Hall of Fame in 1986.
His citation read he had "laid the groundwork for not only a rock and roll sound but a rock and roll stance."
Rolling Stone magazine ranked him 5th in its list of the 100 greatest artists of all time in 2004.
Music was changed forever by Chuck Berry's indescribable impact
Epic Records chairman LA Reid
The music industry reacted with sadness.
The Jacksons said on Twitter: "Chuck Berry merged blues & swing into the phenomenon of early rock 'n' roll. In music, he cast one of the longest shadows. Thank You Chuck."
Huey Lewis, who said he was "maybe the most important figure in all of rock and roll".
"His music and his influence will last forever."
Lewis was joined on social media in tribute to the writer of hit songs including Johnny B Goode and Memphis, Tennessee, by guitar virtuoso Joe Satriani and Randy Jackson, who thanked him for his life's work.
Jackson said: "To the greatest rock and roll pioneer of all time RIP chuck berry. we all thank u"
Guns N' Roses guitarist, Slash, said he was "heartbroken" by the news, and that Berry was "undisputedly the king".
Nikky Sixx of 1980s glam metal band Motley Crue said: "Without him Rock n Roll wouldn't be what it came to be."
The Beatles covered Roll Over Beethoven and drummer Ringo Starr paid tribute to Berry on Twitter.
He said: "Just let me hear some of that rock 'n' roll music any old way you use it.
"I am playing I'm talking about you. God bless Chuck Berry Chuck."
Just let me hear some of that rock 'n' roll music any old way you use it I am playing I'm talking about you. God bless Chuck Berry Chuck 😎 pic.twitter.com/XmwmaGzGpL— #RingoStarr (@ringostarrmusic) March 18, 2017
Whitesnake frontman David Coverdale said: "So sad to share the news of the exceptional Chuck Berry's passing...RIP Chuck..."
Epic Records chairman LA Reid said: "Music was changed forever by Chuck Berry's indescribable impact. What a great life in music."