Spurs have won four of their last five, scoring 20 goals in that time, including a 3-0 win in the group stage a week ago.
It could be another opportunity for Gareth Bale to get minutes under his belt, while Jose Mourinho will hope Carlos Vinicius can put in another good performance in Europe, too.
Antwerp have won their last five in all competitions, beating Ludogorets a week ago in Group J.
Hereâs everything you need to know ahead of the match.
When is the match?
The game kicks off at 5:55pm on Thursday 29 October.
Where can I watch it?
The match will be shown live on BT Sport 2. Subscribers can also stream the match via the BT Sport website or app.
ANT: Butez; Seck, Gelin, De Laet; Miyoshi, Haroun, Hongla, Juklerod; Gerkens, Mbokani, Refaelov
TOT: Lloris, Aurier, Sanchez, Davies, Reguilon, Winks, Dele, Lo Celso, Bergwijn, Bale, Vinicius
Antwerp - 5/1
Draw - 7/2
Tottenham - 4/7