In a video released on social media, Reynolds and Jackman sat down to talk fans through any concerns they may have regarding the film.
The two directly addressed some vocal fan disappointment over the return of Jackman as Wolverine after the character's death in Logan.
Read more: Fans divided over return of Wolverine
They said: "Logan takes place in 2029. Totally separate thing. Logan died in Logan, not touching that."
Quick explainer video that tackles…
1) Timeline questions
2) Logan canon
3) MCU FAQ
4) Whether we can do this all day or not pic.twitter.com/50lBsfYS5p
— Ryan Reynolds (@VancityReynolds) September 28, 2022
Reynolds then says: "What actually happens in our film is these two f***ing guys..." before the audio cuts out and Wham's 'Wake Me Up Before You Go-Go' starts playing as they mime a fight between Deadpool and Wolverine.
The short clip ends with the two thanking Marvel president Kevin Feige and a picture of Reynolds and Jackman with Deadpool 3 director Shawn Levy.
Jackman has played Wolverine 11 times since 2000 but looked to step away from the role after 2017's Logan saw the death of the character and the actor acknowledged it would likely be the last time he played the superhero.
Since then he has appeared in hit musical The Greatest Showman, crime drama Bad Education and sci-fi movie Reminiscence.
Reynolds and Jackman previously starred together in X-Men Origins: Wolverine with the Red Notice actor playing a very different version of Wade Wilson/Deadpool.
That film ended up being a significant commercial and critical disappointment.
Jackman is just the latest X-Men star to cross over into the MCU after Patrick Stewart reprised his role as Professor X in Dr. Strange in the Multiverse of Madness and Evan Peters appeared as Quicksilver in WandaVision.
Deadpool 3 is expected to be released on 6 September, 2024.
Watch below: Hugh Jackman to return as Wolverine in Deadpool 3