Eddie Jones’ men travel to Murrayfield to face the Scots in the third round of matches in the Six Nations.
England have a 100 per cent win record so far from their first two games, with Scotland reacting well after their heavy defeat to Wales to beat the French in the second round of matches.
The last time the two sides met was in last year’s Six Nations campaign; the English thrashed the Scots 61-21 at Twickenham to seal the title with a game to spare.
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Team news and starting line-ups
Scotland are unchanged from their last game, beating France 32-26 at Murrayfield two weeks ago.
Nathan Hughes returns to the starting XV for England, and will be looking to plug holes in the Scotland defensive line from No.8.