The Lions of Teranga were beaten finalists in the last AFCON in Egypt three years ago but are well fancied to go one better this time around, with a star-studded squad.
Guinea also have three points in the bag from their opener, with Issiaga Sylla having earned a 1-0 win against Malawi, but they will be expecting a much sterner test here.
Here’s all you need to know about the game...
Date, kick-off time and venue
Senegal vs Guinea is scheduled for a 1pm GMT kick-off today - Friday, January 14, 2022.
Kouekong Stadium in the Cameroonian city of Bafoussam will host.
Where to watch Senegal vs Guinea
TV channel: In the UK, today’s game will be broadcast live on Sky Sports Main Event, Sky Sports Football and Sky Sports Premier League.
Live stream: Sky Sports subscribers will also be able to watch the game online through the Sky Go app.
LIVE coverage: Get minute-by-minute updates through Standard Sport’s LIVE blog.
Senegal vs Guinea team news
Senegal are expected to remain without Chelsea goalkeeper Edouard Mendy and Napoli centre-back Kalidou Koulibaly after both tested positive for Covid ahead of the tournament.
Still, if they can get through to the next round without much of their spine, it certainly paints a promising picture for the knock-out campaign.
Guinea are also struggling with a Covid outbreak, with seven players having tested positive during their build-up, though key players such as Liverpool’s Naby Keita and Roma’s Amadou Diawara were not among that group and featured in the first game.
Senegal vs Guinea prediction
Senegal have hardly been alone among the tournament favourites in starting the group stage slowly but should be better for the 90 minutes under their belt and can all but book a place in the knockout stage.
Senegal to win 2-0.
Head to head (h2h) history and results
Senegal wins: 25
Guinea wins: 16