The reigning Ukrainian champions hold a potentially crucial 2-1 advantage in this round of 16 tie after Junior Moraes and Marcos Antonio netted either side of a John Brooks goal in the first leg in Germany back in March.
Shakhtar wrapped up their fourth successive domestic title last month, while Wolfsburg finished seventh in the Bundesliga in June, meaning they are guaranteed a place in the second qualifying round of this competition next season.
Either FC Basel or Eintracht Frankfurt will await the winner of this tie in the quarter-finals, with the Swiss side 3-0 up ahead of the return fixture tomorrow night.
Here's how to follow this evening's action....
How to watch
TV channel: The match will be televised live on BT Sport ESPN, with coverage starting from 5.45pm.
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