Saints’ high press and determination saw them sneak a late point off Manchester United on Monday night, leaving them 12th in the table.
Brighton have lost three of the last four, but those defeats came against both Manchester clubs and Liverpool.
Graham Potter’s team have looked impressive when on the front foot, though, and will feel they can attack their reasonably local rivals.
Here’s everything you need to know ahead of the game.
When is it and what time is kick-off?
The match will begin at 8:15pm on Thursday 16 July at St. Mary’s.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport 2 and BT Sport Extra 2. Coverage starts at 8pm.
Southampton: McCarthy, Smallbone, Vestergaard, Bednarek, Vokins, Hojberg, Romeu, Ward-Prowse, Redmond, Ings, Obafemi
Brighton: Ryan, Lamptey, Dunk, Webster, Burn, March, Propper, Stephens, Trossard, Maupay, Murray
What are the odds?
Southampton – 13/10
Draw – 5/2
Brighton – 5/2