The Eagles head into the game following Sunday's impressive draw against Manchester City at Selhurst Park. The Eagles were the first team to take a point off City in the League since August and will set their sights on midtable following a revival under Roy Hodgson.
Palace have lost just once in 10 Premier League matches and could go 13th if results go their way.
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Southampton: McCarthy, Pied, Stephens, Yoshida, Bertrand, Romeu, Hojbjerg, Ward-Prowse, Tadic, Boufal, Long
Subs: Davis, Lemina, Gabbiadini, Redmond, Targett, Bednarek, Forster
Crystal Palace: Hennessey, Fosu-Mensah, Kelly, Tomkins, Schlupp, Cabaye, Milivojevic, McArthur, Townsend, Benteke, Zaha
Subs: Speroni, Van Aanholt, Lee, Souare, Sako, Delaney, Riedewald
Referee: Stuart Attwell (Warwickshire)