England, Wales and Ireland all suffered defeats in their opening games of their southern hemisphere internationals.
England lost 22-17 in Durban, despite a late try from winger Ben Foden.
Stuart Lancaster's men went in level at half time but were left chasing the game in the second half after two quick tries from Fly Half Morne Steyn and Centre Jean De Villiers.
Owen Farrell kept them in touch with the boot but England rarely threatened and came up short.
Wales were beaten 27-19 by Australia while Ireland lost 42-10 against New Zealand.
Julian Savea scored a hat-trick for the All Blacks on his international debut while Dan Carter kicked three penalties and four conversions.
Wales suffered a similar fate against Australia despite a spirited second half fight back.
The Six Nations champions left themselves too much to do after tries from Rob Higginbotham and Will Genia.
Alex Cuthbert did pull a try back and Leigh Halfpenny kicked 14 points as the Wales threatened to pull off a famous comeback, but in the end, it never materialised.