Tedi Fanta, 25, of no fixed address, is charged with the murder of Stephen Dempsey outside the Microsoft store on Thursday.
He is also charged with possession of a knife.
Fanta, who has a previous address in Swansea, appeared at Westminster Magistrates' Court on Saturday.
The defendant, dressed in a grey tracksuit, was assisted by an interpreter during the hearing. He was remanded in custody to appear at the Old Bailey on Tuesday.
Police were called shortly before 8pm on Thursday to reports of a man stabbed at Oxford Circus, close to the junction with Regent Street.
Officers, London Ambulance Service and London's Air Ambulance attended the scene where a 60-year-old man was found with stab injuries.
He was taken to hospital where he later died.
The Met said his next of kin have been informed and are being supported by specially trained officers.
A post-mortem examination will take place in due course.
You can call police on 101 quoting CAD 7129/01Jul. To remain anonymous contact Crimestoppers on 0800 555 111.