It is the first film in the series that does not star Neve Campbell
The film will be released in March.
"And as a woman in this business, I think it's really important for us to be valued," Neve Campbell says of leaving the "Scream" franchise.
It is 25 years since a slasher film quite unlike any other before it ripped through cinema screens.
The actress plays a woman facing the death of her teenage son in the new Disney+ film.