Tony Adams' first match in charge of Granada ended in a comprehensive 3-0 defeat against a second-string Celta Vigo.
Adams, who had been working with the club since November as part of his role with the Chinese owners, admitted Granada need a miracle to avoid relegation.
But there was no sign of that occurring on Sunday as Jozabed's first-half goal and second-half efforts from Marcelo Diaz and Claudio Beauvue clinched victory for Celta.
It looked a golden chance for Granada to take something from the game, with Celta's team selection very much focused on Thursday's Europa League quarter-final.
Celta take a slender 3-2 lead into their second leg against Genk, and goalkeeper Sergio Alvarez is the only player likely to keep his place.
But Granada could not take advantage and remain seven points adrift of safety with six games remaining.
The hosts started well and Andreas Pereira saw a close-range shot blocked in the opening moments before Artem Kravets shot over the bar.
But the incisive play was mostly coming from Celta, and Granada were given a warning in the 19th minute when Beauvue finished off a flowing move by shooting just over the bar.
Four minutes later the visitors took the lead. A defensive mix-up was the catalyst and, when Beauvue found Jozabed, he expertly chipped the ball over Guillermo Ochoa.
The frustration of the home fans was evident as Granada sought a response after the break.
The momentum seemed to be with the home side as first Sverrir Ingason headed wide from a corner, then Pereira swept a shot into the arms of Alvarez before Uche Agbo's powerful, swerving shot from 30 yards hit the bar.
Had that gone in, the result might have been different, but five minutes later Diaz's free-kick found the top corner to effectively end the contest.
Three minutes later it really was all over as Beauvue netted the third, reacting sharply to tuck home after Theo Bongonda's shot had hit the near post.
Granada could not even manage a consolation, Ezequiel Ponce shooting wide from right in front of goal.