Wembley National Stadium Limited's proposal to stage 22 extra full-capacity events at the national team's home was granted by Brent Council last month.
And Spurs have now confirmed they will make the one-season switch to the 90,000-capacity arena while work continues on the site of their new stadium.
The north Londoners had until April 30 to inform the FA of their intentions but have done so ahead of time and are set to play in front of potential crowds of 90,000 on a regular basis next term.
"The Lane means a huge amount to each and every one of us and we needed to gain greater certainty on the delivery of a new stadium before we made the final decision to commence with the decommissioning of our iconic, historic home for some 118 years," a statement from chairman Daniel Levy read.
"We shall ensure that we give the Lane a fitting when we play our last match her on May 14.
"Wembley will be our home for a season and then we shall return to what will be one of the best stadiums of its kind and the most unique in the world playing host to NFL games too - a stadium that will be key to our future growth and success.
Plans to ensure a fitting finale to White Hart Lane will unfold in the coming weeks culminating in a Farewell Ceremony v Man Utd on 14 May. pic.twitter.com/LPhN9EOGTq— Tottenham Hotspur (@SpursOfficial) April 28, 2017
"Both on and off the pitch this in an incredibly exciting time in the history of our club."
Tottenham's decision has also confirmed the current campaign will be their last at White Hart Lane, leaving just two fixtures to be played at the ground starting with Sunday's visit of Arsenal.
The top-flight fixture against Manchester United on May 14 will be the last ever game hosted at the stadium, with Spurs still fighting for the Premier League title and aiming to beat Arsenal in the final north London derby at White Hart Lane that would confirm finishing above their rivals for the first time in 21 years.
Meanwhile, Wembley stadium is understood to have space for five more events within its current cap, which would take the total to 27.
There is believed to be room for negotiation if Spurs progress to the latter stages of the cup competitions they are involved in next season, resulting in additional home games.
Tottenham hope to move into their new 61,000-capacity stadium - a project expected to cost £800m - ahead of the start of the 2018/19 season.
The stadium will be the largest club ground in the capital and is also set to boast a single-tier stand able to house 17,000 supporters, with Spurs hopeful the move can help propel them into the Europe's elite.