The Spurs full-back, who has been linked with a move to top-four rivals Manchester United since the summer, missed the first two months of the season due to a knee ligament injury – making his first appearance of the campaign at Real Madrid in October.
Having slowly returned to the fold since the trip to Spain, making 11 appearances in all competitions, Rose missed the trip to Swansea due to a problem in the same knee.
While Mauricio Pochettino said the England international still needs to be assessed, he confirmed it was ‘impossible’ for Rose to train ahead of Tuesday’s game.
“We need to assess him. After the game against Southampton it was impossible to train and now we are going to assess him. Then the club will give information about what has happened,” Pochettino said.
“I am concerned about everyone when they cannot be available to play. Sometimes it is small things. You know in this situation we cannot manage because I am not a specialist. I am not a doctor.
“Always you are worried because you want the players available and fit to play, so you can make your decision. But we need to wait and we will assess him in the next few days.
The 27-year-old is set to miss the Premier League clash with West Ham on Thursday as well as the FA Cup third round encounter with Wimbledon on Sunday, though Pochettino was remiss to put a timescale on his absence.
“I think I cannot say anything,” he added. “But my feeling, my perception is it would be difficult to play in 48 hours.”