Spurs go into this weekend's Wembley showdown in superb form, having won seven consecutive Premier League games in recent weeks.
The north Londoners were also victorious in their last encounter encounter with the Blues, courtesy of a 2-0 win at White Hart Lane in January.
Such a comprehensive win appeared to lay the demons of last season's 2-2 draw at Stamford Bridge to rest but Lloris is adamant Spurs will have to be at the peak of their mental powers again to get past Antonio Conte's men.
"It'll be a big battle psychologically - the mental will be more important [than the physical]," Lloris told ESPN.
"We want to go through. We know Chelsea is a great team and it'll be a big fight on the pitch but we'll be ready for that.
"We expect a tough game and we worked hard all season to ready to enjoy this kind of game.
"A semi-final at Wembley is an exciting moment for a young team."
Mauricio Pochettino, who is convinced Chelsea should be regarded as favourites to progress, is adamant Spurs will not be provoked into losing their cool like they did at 'The Battle of Stamford Bridge'.
Captain Lloris will be central to Spurs keeping their composure and the Frenchman is adamant he and his teammates are focused on themselves rather than their opponents.
"We have a lot of respect for Chelsea. They've been great all season.
"They're competitors. We're not focused on the players we are going to face - we're just focused on ourselves," he added.