Kane rose to prominence in the 2014-15 season and swatted aside premature 'one-season wonder' jibes en route to the Premier League golden boot last term.
The 23-year-old is vying to win the award again this season, despite suffering two separate ankle ligament injuries.
Alli is also a key figure in Mauricio Pochettino's side, having twice won the PFA Young Player of the Year award since joining up with the Spurs first-team in the summer of 2015.
Reid will be charged with stopping both men on Friday night and the 28-year-old is full of admiration for the Spurs duo.
“Dele Alli is a very good player, first of all," Reid told West Ham's official website.
"He’s been able to do it in his second season, when sometimes you have young players who are able to do it for one season, and they can’t sustain it.
“He’s done really well again and that says a lot about his ability, and you can say the same about Harry Kane.
“In the first season he broke through in 2014-15, he scored a lot of goals, then he did it in his second season.
"Now he’s done it in a third, so I think that shows he has some real quality,” the defender added.
Spurs remain in the title race and will cut Chelsea's lead at the top of the Premier League table to just one point if they are victorious at London Stadium.
The Hammers, meanwhile, are languishing in 15th place and need one more victory to secure their top-flight status for another season.