The Welshman did not feature at Wembley but has been recalled to the side along with Kyle Walker as Spurs stick with a 3-4-2-1 formation.
Mauricio Pochettino's side lost to Chelsea in the FA Cup semi-finals last time out and will be determined to get back to winning ways at Selhurst Park.
The north Londoners are seven points adrift of Antonio Conte's side and need a positive result to keep up the pressure on the division's pacesetters.
Tottenham XI: Lloris, Walker, Dier, Alderweireld, Vertonghen, Davies, Wanyama, Dembele, Eriksen, Dele, Kane.
Tottenham subs: Lopez, Trippier, Wimmer, Sissoko, Nkoudou, Son, Janssen.
Crystal Palace XI: Hennessey, Ward, Kelly, Sakho, Schlupp, Milivojevic, Puncheon, McArthur, Zaha, Townsend, Benteke.
Crystal Palace subs: Speroni, Van Aanholt, Delaney, Cabaye, Sako, Flamini, Campbell.
What they're saying
Mauricio Pochettino: "We need to be strong. We need to be aware of that, they will fight a lot to try to beat us.
"When you are playing for the title, playing to be in the top four, what that game means is so important."
Sam Allardyce: "The players have done a fantastic job but I just hope they don’t come off the gas and think we've done it.
"I hope the game is big enough [against Tottenham] to ensure that they don’t take their foot off the gas.”